There are no agent settings that bind the Uptime Infrastructure Monitor to a specific network interface. By default, the UIM agent is designed to listen to all interfaces on port 9998.
It is possible to provide alternate options. For example, if you are using the UIM Linux agent and running via xinetd, you can edit the agent xinetd script (/etc/xinetd.d/uptmagnt) to bind to a specific interface. For more information about this task, see Access Control Using xinetd on the Red Hat/CentOS site.