AlwaysOn Availability Groups are part of an integrated solution, introduced in SQL Server 2012 to achieve the highest level of data availability and disaster recovery for organizations.
Availability Groups allow databases to automatically or manually failover a group of databases as a single unit with support for up to four secondary replicas.
SQL Safe supports SQL Server Availability Groups and allows you to perform backup and recovery strategies on your primary and secondary replicas.
To install and configure SQL Safe for use with Availability Groups, go to register your SQL Server.
Keep in mind that an agent needs to be installed on all nodes in the availability group that will be considered for backups.
For additional information on availability groups, see the Microsoft document, Overview of AlwaysOn Availability Groups (SQL Server).